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The Delta SkyMiles® Reserve Business Amex Card is the top-of-the-line choice for frequent Delta flyers, offering perks like 3X miles on Delta purchases, an annual Companion Certificate and 15 Sky Club visits. If you frequently fly in and out of Delta hubs like Atlanta, Boston or Cincinnati, this card can significantly improve your flying experience. However, the $650 annual fee (see rates and fees) and limited lounge access starting in 2025 may not suit everyone, especially if you don’t fly in and out of Delta hubs often enough to enjoy the card’s premium perks.